Expert Analysis:
Mitochondrial DNA

June 8, 2016

Mitochondrial replacement in human embryos edges towards treatment for genetic disease

The first results from mitochondrial replacement, which some refer to as ‘3-person IVF’, in normally fertilized human embryos has been reported in Nature. The researchers improved their technique to reduce mutant DNA to levels at which a child would be unlikely to develop mitochondrial disease Continue reading

May 19, 2016

Mitochondrial replacement: Study identifies challenge for effectiveness of potential therapies

Researchers report that a small amount of mitochondrial DNA carried over in mitochondrial replacement techniques can occasionally increase over time, which could pose a problem for clinical therapies aiming to completely remove faulty mitochondrial DNA. Continue reading

July 15, 2015

Stem cells offer alternative approach to develop therapies for inherited mitochondrial disorders

Genetically corrected pluripotent stem cells derived from patients with inherited mitochondrial disorders offer a new approach to developing therapies for these incurable diseases, according to a study published in Nature Continue reading

April 23, 2015

Researchers gene-edit mouse egg cells, suggest potential use in humans for preventing mitochondrial disease

Scientists have suggested a potential alternative to controversial mitochondrial replacement, so called ‘3-person IVF’, for preventing inherited genetic disorders by using genome-editing technology to prevent specific mitochondrial DNA from being passed from mothers to offspring in mice. The study also reported the technique was used to correct human mitochondrial DNA inserted into mouse egg cells. Continue reading