Expert Analysis:
Emerging Genetic Technologies

July 8, 2016

Patient deaths halt clinical trial testing genetically engineered cells to treat cancer

Three patients have died in a clinical trial that is testing the use of genetically engineered immune cells known as CAR-T cells to treat acute lymphoblastic leukemia in adults. Continue reading

June 21, 2016

First clinical trial using CRISPR approved by National Institutes of Health advisory panel

A proposal for the first clinical trial involving CRISPR-Cas9 gene editing has been approved by the National Institutes of Health Recombinant DNA Advisory Committee. The Phase I trial, which will require approval from the Food and Drug Administration, is designed … Continue reading

May 20, 2016

Researchers report using CRISPR to remove HIV DNA in live animals for the first time

The removal of HIV virus DNA from the genomes of live animals using CRISPR-Cas9 has been reported in the journal Gene Therapy. Continue reading

May 13, 2016

Harvard meeting on synthesizing human genome questioned over secrecy

A project that would synthesize a complete human genome and test it in cells within 10 years was discussed at a meeting of scientists, ethicists, lawyers, and entrepreneurs at Harvard University on May 10. Continue reading

April 20, 2016

CRISPR made even more precise, used to correct mutations linked to disease risk

Researchers have developed a modified version of CRISPR-Cas9 that can edit single letters of DNA without breaking the double helix, according to a paper in Nature. The authors say their method is more efficient and has fewer off-target effects than previous methods. Continue reading

April 8, 2016

Second paper to report gene-editing in human embryos published

The second paper reporting gene-editing in nonviable human embryos from IVF clinics has been published in the Journal of Assisted Reproduction and Genetics. Continue reading

February 3, 2016

Ethics panel: US should allow embryos with mitochondrial DNA from a third person

A panel of scientists and ethicists have said the US should allow clinical research into preventing genetic diseases by mitochondrial replacement, a technique which involves substituting the faulty mitochondria in a mother’s eggs with healthy mitochondria from a donor. Continue reading

February 1, 2016

UK fertility regulator approves research project to gene-edit human embryos

A research project to gene-edit human embryos has been given the go-ahead by the UK’s Human Fertilisation and Embryology Authority. The approval has been granted to the Francis Crick Institute for research into the genes needed for embryos to develop successfully. Continue reading

December 16, 2015

Government spending bill restricts research with gene-edited human embryos – but how far?

The major US government spending bill, agreed on Tuesday and set to be passed by Congress on Friday, includes a prohibition of the use of federal funds by the Food and Drug Administration to consider human embryos “intentionally created or modified to include a heritable genetic modification”. GENeS has asked experts in biomedical law what restrictions the bill would put on research using gene-editing on human embryos. Continue reading

December 3, 2015

Organizers of global scientific meeting back cautious use of gene-editing in humans

At the close of the international summit on human gene-editing, the organizers released a statement saying it would be “irresponsible to proceed with any clinical use of germline editing” until the risks were better understood, but fell short of endorsing a moratorium on human germline gene-editing. Continue reading

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